Table 1 provides a detailed breakdown of the disease categories included in DiReCT. As some premise may not included in the referred guidelines.

While the ICD code assignment problem has been widely studied, most works have focused on post-discharge document classification. Models for early forecasting of this information could be used for identifying health risks, suggesting effective treatments, or optimizing resource allocation. To address the challenge of predictive modeling using the limited information at the beginning of a patient stay, we propose a multimodal system to fuse clinical notes and tabular events captured in electronic health records. The model integrates pre-trained encoders, feature pooling, and cross-modal attention to learn optimal representations across modalities and balance their presence at every temporal point. Moreover, we present a weighted temporal loss that adjusts its contribution at each point in time. Experiments show that these strategies enhance the early prediction model, outperforming the current state-of-the-art systems.

Artificial intelligence (AI) has potential to revolutionize the field of oncology by enhancing the precision of cancer diagnosis, optimizing treatment strategies, and personalizing therapies for a variety of cancers. This review examines the limitations of conventional diagnostic techniques and explores the transformative role of AI in diagnosing and treating cancers such as lung, breast, colorectal, liver, stomach, esophageal, cervical, thyroid, prostate, and skin cancers. The primary objective of this paper is to highlight the significant advancements that AI algorithms have brought to oncology within the medical industry. By enabling early cancer detection, improving diagnostic accuracy, and facilitating targeted treatment delivery, AI contributes to substantial improvements in patient outcomes. The integration of AI in medical imaging, genomic analysis, and pathology enhances diagnostic precision and introduces a novel, less invasive approach to cancer screening. This not only boosts the effectiveness of medical facilities but also reduces operational costs. The study delves into the application of AI in radiomics for detailed cancer characterization, predictive analytics for identifying associated risks, and the development of algorithm-driven robots for immediate diagnosis. Furthermore, it investigates the impact of AI on addressing healthcare challenges, particularly in underserved and remote regions. The overarching goal of this platform is to support the development of expert recommendations and to provide universal, efficient diagnostic procedures. By reviewing existing research and clinical studies, this paper underscores the pivotal role of AI in improving the overall cancer care system. It emphasizes how AI-enabled systems can enhance clinical decision-making and expand treatment options, thereby underscoring the importance of AI in advancing precision oncology

Large language models (LLMs) primarily trained on English texts, often face biases and inaccuracies in Chinese contexts. Their limitations are pronounced in fields like Traditional Chinese Medicine (TCM), where cultural and clinical subtleties are vital, further hindered by a lack of domain-specific data, such as rheumatoid arthritis (RA). To address these issues, this paper introduces Hengqin-RA-v1, the first large language model specifically tailored for TCM with a focus on diagnosing and treating RA. We also present HQ-GCM-RA-C1, a comprehensive RA-specific dataset curated from ancient Chinese medical literature, classical texts, and modern clinical studies. This dataset empowers Hengqin-RA-v1 to deliver accurate and culturally informed responses, effectively bridging the gaps left by general-purpose models. Extensive experiments demonstrate that Hengqin-RA-v1 outperforms state-of-the-art models, even surpassing the diagnostic accuracy of TCM practitioners in certain cases.

Mental health disorders are one of the most serious diseases in the world. Most people with such a disease lack access to adequate care, which highlights the importance of training models for the diagnosis and treatment of mental health disorders. However, in the mental health domain, privacy concerns limit the accessibility of personalized treatment data, making it challenging to build powerful models. In this paper, we introduce MentalArena, a self-play framework to train language models by generating domain-specific personalized data, where we obtain a better model capable of making a personalized diagnosis and treatment (as a therapist) and providing information (as a patient). To accurately model human-like mental health patients, we devise Symptom Encoder, which simulates a real patient from both cognition and behavior perspectives. To address intent bias during patient-therapist interactions, we propose Symptom Decoder to compare diagnosed symptoms with encoded symptoms, and dynamically manage the dialogue between patient and therapist according to the identified deviations. We evaluated MentalArena against 6 benchmarks, including biomedicalQA and mental health tasks, compared to 6 advanced models. Our models, fine-tuned on both GPT-3.5 and Llama-3-8b, significantly outperform their counterparts, including GPT-4o. We hope that our work can inspire future research on personalized care. Code is available in https://github.com/Scarelette/MentalArena/tree/main

This study addresses the challenge of stroke diagnosis and treatment under uncertainty, a critical issue given the rapid progression and severe consequences of stroke conditions such as aneurysms, arteriovenous malformations (AVM), and occlusions. Current diagnostic methods, including Digital Subtraction Angiography (DSA), face limitations due to high costs and its invasive nature. To overcome these challenges, we propose a novel approach using a Partially Observable Markov Decision Process (POMDP) framework. Our model integrates advanced diagnostic tools and treatment approaches with a decision-making algorithm that accounts for the inherent uncertainties in stroke diagnosis. Our approach combines noisy observations from CT scans, Siriraj scores, and DSA reports to inform the subsequent treatment options. We utilize the online solver DESPOT, which employs tree-search methods and particle filters, to simulate potential future scenarios and guide our strategies. The results indicate that our POMDP framework balances diagnostic and treatment objectives, striking a tradeoff between the need for precise stroke identification via invasive procedures like DSA and the constraints of limited healthcare resources that necessitate more cost-effective strategies, such as in-hospital or at-home observation, by relying only relying on simulation rollouts and not imposing any prior knowledge. Our study offers a significant contribution by presenting a systematic framework that optimally integrates diagnostic and treatment processes for stroke and accounting for various uncertainties, thereby improving care and outcomes in stroke management.

The vision of IASIS project is to turn the wave of big biomedical data heading our way into actionable knowledge for decision makers. This is achieved by integrating data from disparate sources, including genomics, electronic health records and bibliography, and applying advanced analytics methods to discover useful patterns. The goal is to turn large amounts of available data into actionable information to authorities for planning public health activities and policies. The integration and analysis of these heterogeneous sources of information will enable the best decisions to be made, allowing for diagnosis and treatment to be personalised to each individual. The project offers a common representation schema for the heterogeneous data sources. The iASiS infrastructure is able to convert clinical notes into usable data, combine them with genomic data, related bibliography, image data and more, and create a global knowledge base. This facilitates the use of intelligent methods in order to discover useful patterns across different resources. Using semantic integration of data gives the opportunity to generate information that is rich, auditable and reliable. This information can be used to provide better care, reduce errors and create more confidence in sharing data, thus providing more insights and opportunities. Data resources for two different disease categories are explored within the iASiS use cases, dementia and lung cancer.

During the middle of the 20th century, scientists and social theorists began to fear the problem of overpopulation, predicting a period of mass starvation. Famously, Stanford's Paul Ehrlich, in his 1968 book, "The Population Bomb" predicted "the battle to feed all of humanity is over...hundreds of millions of people will starve to death in spite of any crash programs embarked upon now." At the time, his pessimistic thinking was not isolated. Simultaneously, Norman Borlaug became a pioneer in wheat production with his work in genetics powering new ways to grow crops. His "Green Revolution" for which he received the 1970 Nobel Peace Prize, is credited with saving over a billion lives.

Scientists at the Max Planck Institute for Intelligent Systems in Stuttgart have developed a soft robotic tool that promises to one day transform minimally invasive endovascular surgery. The two-part magnetic tool can help to visualise in real time the fine morphological details of partial vascular blockages such as stenoses, even in the narrowest and most curved vessels. It can also find its way through severe blockages such as chronic total occlusions. This tool could one day take the perception of endovascular medical devices a step further. Intravascular imaging techniques and microcatheter procedures are becoming ever more advanced, revolutionizing the diagnosis and treatment of many diseases.